ABSTRACT
Background: Helicobacter Pylori is a common infection highly prevalent globally causing chronic gastritis, duodenal ulcer and gastric carcinoma. It is observed clinically that patients who underwent therapy for eradication of H Pylori developed weight gain. Objective of this study was to evaluate the association between weight gain and eradication of H pylori infection
Method: For this observational cross sectional study, 137 patients were studied after confirmation of diagnosis of H pylori. Base line data at the beginning of the study and comparison between pre- treatment and post treatment outcomes were assessed after 3 months of follow up
Result: After eradication therapy, a difference in body weight was evident from pre-treatment mean body weight of 61.7+/-12.3 kg to 62.5+/-11.2 Kg [P=0.011]. An increase in BMI was recorded from pretreatment BMI of 23.24 +/-2.1Kg/m[2] to 26.4+/-3.8 Kg/m[2] [P=0.028]. The assessment of symptoms was performed by applying Mann-Whitney U test of significance; score of symptoms showed a decline in intensity after eradication therapy. Mean score of dyspepsia decreased from 2.65 to 1.02 with a P value of 0.024, mean score of epigastric pain from 2.73 to 1.14 [P=0.041], mean upper abdomen fullness from 2.49 to 0.35[P=0.021]. A decrease in heart burn was noted 3.46 vs 0.92 [P=0.003] and loss of appetite was less severe; 2.89 vs 0.58 [P=0.011]
Conclusion: The eradication of H Pylori, after 3 months of treatment, is associated with mild weight gain
ABSTRACT
Objective: to study clinical localization of stroke and correlate with findings on C-T Scan of Brain
Design: observational study
Place and Duration of study: the study was conducted at the Medical Department of Liaquat University Hospital Hyderabad/Jamshoro from January 2006 to December 2006
Material and Methods: total 110 patients with features of stroke were included in this study. These patients were further evaluated for clinical correlation with findings on CT scan brain, done within 24 hours after the development of focal neurological deficit. Brain tumor, meningitis, viral or bacterial encephalitis, multiple sclerosis and metabolic derangements that could explain focal neurological deficit e.g hypoglycemia were` the exclusion parameters
Results: total of 110 patients, 60 [54.5%] were males and 50 [45.5%] were females. Age of patients ranged 22-84 years with mean +/- SD age of 53 +/- 5 years. On clinical ground cerebral infarction was suspected in 89 [80.9%] and cerebral hemorrhage in 21 [19.1%] patients. In 74 [83%] patients infarction was confirmed by CT scan brain, whereas cerebral hemorrhage was proved in 10 [47.6%] out of a total of 21 patients. These patients were further evaluated for clinical localization of area of stroke. Clinically left parietal / temporo parietal lobe infarction was suspected in 43 patients and right parietal / temporo parietal lobe in 25 patients. Left frontal lobe infarction in 7 patients right frontal lobe infarction in 8 patients, left internal capsule infarction in 2 patients and right internal capsule infarction in 4 patients. Comparing with the CT scan brain findings: left parietal / temporo parietal lobe infarction was confirmed in 41 [95.34%] patients, right parietal / temporo parietal lobe in 19 [76%], left frontal lobe in 5 [71.4%], right frontal lobe in 4 [50%], left internal capsule in 2 [100%] and right internal capsule in 3 [75%] patients. Left middle cerebral artery territory involvement was observed in 43 [58%] patients and right middle cerebral artery territory in 22[30%] patients. No Significant difference was observed in other cerebral artery territories
Conclusion: it was concluded from the study that cerebral infarction was more common than hemorrhage and middle cerebral artery territory infarction of both sides was more common than other cerebral artery territories. Localization of stroke on clinical basis is not always easy. Confident diagnosis requires careful case history taking, extensive neurological assessment and with the help of focal neurological deficit of a particular area
Category: internal Medicine
ABSTRACT
Objective: To study the cutaneous manifestations in type-II diabetic patients in our tertiary care setup. Setting: This study was carried out in Medicine Department, Liaquat University Hospital Jamshoro/ Hyderabad, Sindh - Pakistan; from January to December 2005
Methods: Diabetic patients who had skin problems were selected for the study with convenience sampling technique. Then questionnaires were filled for collection of the data
Results: In this study, 72% diabetics had skin infections, whereas 28% patients had non infectious lesions. Fungal infections were the most commonest [50%], followed by 14.4% bacterial infections and viral infections [7.77%]. Among fungal infections, Candida albicans was commonest [22.2%]. The non infectious lesions were skin tags [8.8%], xanthomas [6.6%], and pruiritis [6.6%]
ABSTRACT
Objective: To determine the frequency of night blindness among cirrhotic patients and evaluate the restoration of vision with vitamin A therapy. Design: - Case-control observational study. Setting: Medical ward of Liaquat University Hospital Hyderabad / Jamshoro, Sindh - Pakistan; from January 2006 to December 2007
Methods: Two hundred cirrhotic patients admitted at medical unit IV were enrolled in the study. The non-cirrhotic patients were excluded. Fifty healthy volunteers took part as the control subjects
Results: Out of 200 patient, 116[58%] were males and 84[42%] females. The mean age of the cirrhotic patients was 48.46 + 11.97 years. The cause of cirrhosis was hepatitis C virus in 146 [73%] cases, hepatitis B virus in 19[9.5%] cases, hepatitis C and B virus in 7[3.5%] cases, non B and C virus in 24[12%] cases and alcohol in 4[2%] cases. When cirrhotic patients were grouped into Child-Pugh's score, 44[22%] were in class A, 106 [53%] in class B and 50[25%] in class C. Among 200 patients, 122 [61%] had history of night blindness and 25[12.5%] had the colour blindness. Restoration of vision was observed in 105[86%] patients with vitamin A therapy [tablet Vitamin A 50,000 IU, Wilson Pharma], twice daily, for 6 weeks time
Conclusion: The history of night blindness and its restoration of vision with vitamin A therapy is a rough indicator of vitamin A deficiency in cirrhotic patients. The larger studies are required especially RBP [plasma retinol binding protein] and serum vitamin A concentration before recommendation of vitamin A replacement. The Ophthalmic changes in cirrhotic patients are preventable and treatable
ABSTRACT
Objective: To determine the frequency of various risk factors for stroke and its sub-types among males and females. Design: Cross sectional /Observational study. Place and Duration of Study: The study was conducted at the Medical Department of Liaquat University Hospital Hyderabad/Jamshoro from January 2006 to March 2007
Material and Methods: Patients with features of stroke confirmed by CT scan brain were enrolled. Brain imaging showing abnormality e.g. brain tumour, meningitis, multiple sclerosis and metabolic derangements that could explain focal neurologic deficit were the exclusion parameters. The frequency of various risk factors for stroke and its types among males and females were evaluated
Results: Out of total 100 patients, 78[78%] presented with infarction stroke and 22[22%] with hemorrhagic stroke. Their mean age at presentation was 56.89 with SD=8.92 years. Hypertension 35[59.3%] and smoking 18[94.7%] were the most important risk factors among males, while the presence of diabetes mellitus 16[55.2%] and IHD 10[62.5%] were found to be more common among females. Forty-two [42%] and 11[11%] males, while 36[36.3%] and 11[11%] females suffering from cerebral infarction and cerebral hemorrhage respectively. In-hospital mortality was 09[09%]
Conclusion: Frequency of various risk factors was high in this study which is similar to that observed in developed countries. Hypertension and smoking were the major risk factors for males, while diabetes mellitus and IHD were more common in females. We did not find any significant gender difference between the two stroke types. Category: Internal Medicine